ASL homeostasis

mucus_clearance_cells

Adapted from Zeitlin 2008 J Clin Invest 118(12):3841-3844

Cystic fibrosis is a genetic disease characterized by the build-up of thick mucus. Mucus clearance is important for the prevention of airway infection and is comprised of three main components: mucus, cilia, and the airway surface liquid. The cilia, outstretched in the airway surface liquid, work like a brush to remove the pathogen-trapping mucus from the airways.

In cystic fibrosis, the airway surface liquid (ASL), is dehydrated, which impacts mucus clearance.  We are using MATLAB-based mathematical modeling and analysis to understand how ASL dehydration in CF occurs and to identify possible avenues of airway rehydration.